Antimicrobial and Hemolytic Activities of Copolymers with Cationic and Hydrophobic Groups: A Comparison of Block and Random Copolymers | Zendy

Wang Yanqiang | Zendy; Xu Junjuan | Zendy; Zhang Yueheng | Zendy; Yan Husheng | Zendy; Liu Keliang | Zendy

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Antimicrobial and Hemolytic Activities of Copolymers with Cationic and Hydrophobic Groups: A Comparison of Block and Random Copolymers

Author(s) -

Wang Yanqiang,

Xu Junjuan,

Zhang Yueheng,

Yan Husheng,

Liu Keliang

Publication year - 2011

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.201100196

Subject(s) - copolymer , cationic polymerization , methacrylate , chemistry , polymer chemistry , antimicrobial , polymer , organic chemistry

Random and diblock copolymers of 2‐( N,N ‐dimethylamino)ethyl methacrylate and butyl methacrylate are prepared by ATRP. As mimics of cationic antimicrobial peptides, the random and diblock copolymers show similar antimicrobial activities. In contrast, the diblock copolymers have much lower hemolytic activities than the random copolymers. The cell selectivity (HC 50 /MIC, where HC 50 is the concentration to lyse 50% of human red blood cells and MIC is the minimum concentration to inhibit bacterial growth) of the diblock copolymers are 150 to 27 500 times higher than that of random copolymers with similar compositions.

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