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Pullulan Hydrogels Improve Mesenchymal Stem Cell Delivery into High‐Oxidative‐Stress Wounds
Author(s) -
Wong Victor W.,
Rustad Kristine C.,
Glotzbach Jason P.,
Sorkin Michael,
Inayathullah Mohammed,
Major Melanie R.,
Longaker Michael T.,
Rajadas Jayakumar,
Gurtner Geoffrey C.
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100180
Subject(s) - pullulan , self healing hydrogels , mesenchymal stem cell , oxidative stress , chemistry , stem cell , cell , regeneration (biology) , wound healing , progenitor cell , microbiology and biotechnology , biochemistry , immunology , biology , polysaccharide , polymer chemistry
Cell‐based therapies for wound repair are limited by inefficient delivery systems that fail to protect cells from the acute inflammatory environment. Here, a biomimetic hydrogel system is described that is based on the polymer pullulan, a carbohydrate glucan known to exhibit potent antioxidant capabilities. It is shown that pullulan hydrogels are an effective cell delivery system and improve mesenchymal stem cell survival and engraftment in high‐oxidative‐stress environments. The results suggest that glucan hydrogel systems may prove beneficial for progenitor‐cell‐based approaches to skin regeneration.