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Micelles from Amphiphilic Block Copolyphosphates for Drug Delivery
Author(s) -
Zhai Xiang,
Huang Wei,
Liu Jinyao,
Pang Yan,
Zhu Xinyuan,
Zhou Yongfeng,
Yan Deyue
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100163
Subject(s) - micelle , amphiphile , chemistry , drug delivery , hela , drug , monomer , drug carrier , combinatorial chemistry , copolymer , biophysics , polymer , organic chemistry , aqueous solution , biochemistry , pharmacology , cell , medicine , biology
Amphiphilic block copolyphosphates (PEP ‐b‐ PIPPs) are synthesized by two‐step ROP of cyclic phosphate monomers with different pedant groups. They can spontaneously self‐assemble into approximately spherical micelles ranging in size between 89 and 198 nm in water. A typical hydrophobic anti‐cancer drug DOX is encapsulated into the micelles. The release rate of DOX slows down with increasing hydrophobic block length of PIPP. DOX‐loaded micelles are investigated for the proliferation inhibition of Hela cells and the DOX dose required for 50% cellular growth inhibition is found to be 0.8 µg mL −1 . It is demonstrated that PEP ‐b‐ PIPP micelles can be used as a safe and promising drug delivery system.