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Emulsion Electrospinning of a Collagen‐Like Protein/PLGA Fibrous Scaffold: Empirical Modeling and Preliminary Release Assessment of Encapsulated Protein
Author(s) -
Wei Kai,
Li Yuan,
Lei Xiaowen,
Yang Heejae,
Teramoto Akira,
Yao Juming,
Abe Koji,
Ko Frank K.
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100141
Subject(s) - electrospinning , plga , emulsion , scaffold , fluorescence microscope , chemical engineering , chemistry , biomedical engineering , materials science , polymer chemistry , polymer , biophysics , composite material , fluorescence , nanotechnology , nanoparticle , organic chemistry , medicine , physics , engineering , quantum mechanics , biology
The effectiveness of a multifunctional scaffold produced by the electrospinning of emulsions composed of organic PLGA and aqueous collagen‐like protein (denoted as Fol‐8Col) solutions is demonstrated. The resultant Fol‐8Col/PLGA fibrous scaffolds with homogeneous morphology have mean fiber diameters from 600 to 2 000 nm. A uniform distribution of encapsulated Fol‐8Col in the fibers is observed by fluorescence microscopy. TEM is used to clarify the representative core/sheath structure of emulsion electrospun Fol‐8Col/PLGA fibers. Preliminary release assessment of encapsulated Fol‐8Col shows results of sustained release for more than one month from the Fol‐8Col/PLGA fibrous mats. The cytocompatibility of fibroblast cell line L929 with the fibrous composite seems promosing.