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Self‐Assembled Antimicrobial and Biocompatible Copolymer Films on Titanium
Author(s) -
Pfaffenroth Cornelia,
Winkel Andreas,
Dempwolf Wibke,
Gamble Lara J.,
Castner David G.,
Stiesch Meike,
Menzel Henning
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100124
Subject(s) - biocompatibility , copolymer , contact angle , titanium , antimicrobial , adhesion , biofilm , materials science , chemical engineering , chemistry , biocompatible material , polymer chemistry , biomedical engineering , organic chemistry , polymer , composite material , bacteria , biology , engineering , genetics , medicine
Copolymers of 4‐vinyl‐ N ‐hexylpyridinium bromide and dimethyl(2‐methacryloyloxyethyl) phosphonate self‐assemble to form ultrathin layers on titanium surfaces that show antimicrobial activity, and biocompatibility. The copolymer layers are characterized by contact angle measurements, ellipsometry and XPS. Antibacterial activity is assessed by investigation of adherence of S. mutans . Biocompatibility is rated based on human gingival fibroblast adhesion and proliferation. By balancing the opposing effects of the chemical composition on biocompatibility and antimicrobial activity, copolymer coatings are fabricated that are able to inhibit the growth of S. mutans on the surface but still show attachment of gingival fibroblasts, and therefore might prevent biofilm formation on implants.