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Layer‐by‐Layer Assembled Multilayer Films of Methoxypoly(ethylene glycol) ‐block‐ poly( α, L ‐glutamic acid) and Chitosan with Reduced Cell Adhesion
Author(s) -
Cao Bin,
Yan Shifeng,
Zhang Kunxi,
Song Zhijiang,
Chen Xuesi,
Cui Lei,
Yin Jingbo
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100053
Subject(s) - ethylene glycol , contact angle , copolymer , adhesion , chitosan , polymer chemistry , layer (electronics) , chemical engineering , materials science , substrate (aquarium) , quartz crystal microbalance , layer by layer , chemistry , polymer , nanotechnology , adsorption , organic chemistry , composite material , oceanography , geology , engineering
A methoxypoly(ethylene glycol) ‐block‐ poly( α , L ‐glutamic acid) (mPEGGA) diblock copolymer is synthesized. Using QCM measurements, it is shown that (CS/mPEGGA) n film construction takes place over two build‐up stages (exponential‐to‐linear). UV‐vis spectra reveal the regular increase of the multilayer film growth at different molecular weights of mPEGGA. Contact angle and surface morphology investigation prove that the hydrophilicity of CS/mPEGGA multilayer film‐modified substrate becomes better and the surface becomes rough. Significantly reduced cell adhesion is observed on the CS/mPEGGA multilayer film coated surface.