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In vitro Characterization of an Electroactive Carbon‐Nanotube‐Based Nanofiber Scaffold for Tissue Engineering
Author(s) -
Mackle Joseph N.,
Blond David J.P.,
Mooney Emma,
McDonnell Caitlin,
Blau Werner J.,
Shaw Georgina,
Barry Frank P.,
Murphy J. Mary,
Barron Valerie
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100029
Subject(s) - scaffold , tissue engineering , nanofiber , characterization (materials science) , carbon nanotube , nanotechnology , mesenchymal stem cell , materials science , biomedical engineering , polymer , electrospinning , chemistry , nanotube , composite material , microbiology and biotechnology , medicine , biology
Abstract In an effort to reduce organ replacement and enhance tissue repair, there has been a tremendous effort to create biomechanically optimized scaffolds for tissue engineering applications. In contrast, the development and characterization of electroactive scaffolds has attracted little attention. Consequently, the creation and characterization of a carbon nanotube based poly(lactic acid) nanofiber scaffold is described herein. After 28 d in physiological solution at 37 °C, a change in the mass, chemical properties and polymer morphology is seen, while the mechanical properties and physical integrity are unaltered. No adverse cytotoxic affects are seen when mesenchymal stem cells are cultured in the presence of the scaffold. Taken together, these data auger well for electroactive tissue engineering.