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A Poly(acrylic acid) ‐block‐ Poly( L ‐glutamic acid) Diblock Copolymer with Improved Cell Adhesion for Surface Modification
Author(s) -
Cao Bin,
Yan Shifeng,
Zhang Kunxi,
Song Zhijiang,
Cao Tian,
Chen Xuesi,
Cui Lei,
Yin Jingbo
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100010
Subject(s) - copolymer , biocompatibility , acrylic acid , surface modification , adhesion , cell adhesion , polymer chemistry , plga , adhesive , materials science , chemical engineering , chemistry , polymer , nanotechnology , organic chemistry , layer (electronics) , nanoparticle , engineering
A novel PAA ‐b‐ PLGA diblock copolymer is synthesized and characterized that has excellent cell adhesion and biocompatibility. Fluorescent DiO labeling is used to monitor the attachment and growth of hASCs on the film surface, and cell proliferation over time is studied. Results show that PLLA modified by a CS/PAA ‐b‐ PLGA multilayer film can promote the attachment of human hASCs and provide an advantageous environment for their proliferation. The multilayer film presents excellent biocompatibility and cell adhesive properties, which will provide a new choice for improving the cell attachment in surface modification for tissue engineering. Hydroxyl, carboxyl and amine groups in the CS/PAA ‐b‐ PLGA multilayer film may be combined with drugs and growth factors for therapy and differentiation.