Nitrogen‐Rich Plasma‐Polymerized Coatings on PET and PTFE Surfaces Improve Endothelial Cell Attachment and Resistance to Shear Flow | Zendy

Gigout Anne | Zendy; Ruiz JuanCarlos | Zendy; Wertheimer Michael R. | Zendy; Jolicoeur Mario | Zendy; Lerouge Sophie | Zendy

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Nitrogen‐Rich Plasma‐Polymerized Coatings on PET and PTFE Surfaces Improve Endothelial Cell Attachment and Resistance to Shear Flow

Author(s) -

Gigout Anne,

Ruiz JuanCarlos,

Wertheimer Michael R.,

Jolicoeur Mario,

Lerouge Sophie

Publication year - 2011

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.201000512

Subject(s) - plasma polymerization , seeding , adhesion , materials science , shear stress , gelatin , cell adhesion , composite material , biomedical engineering , endothelial stem cell , polymerization , atmospheric pressure plasma , shear (geology) , chemistry , biophysics , plasma , in vitro , polymer , biochemistry , medicine , physics , quantum mechanics , engineering , biology , aerospace engineering

Low seeding efficiency and poor cell retention under flow‐induced shear stress limit the effectiveness of in vitro endothelialization strategies for small‐diameter vascular grafts. Primary‐amine‐rich plasma‐polymerized coatings (PPE:N) deposited using low‐ and atmospheric‐pressure plasma discharges on PET and PTFE are evaluated for their ability to improve endothelial cells' kinetics and strength of attachment. PPE:N coatings increase cell adhesion and adhesion rate, spreading, focal adhesion, and resistance to flow‐induced shear compared with bare and gelatin‐coated PET and PTFE. In particular, about 90% of the cells remain on coated surfaces after 1 h exposure to shear. These coatings, therefore, appear as a promising versatile approach to improve cell seeding strategies for vascular grafts.

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