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Poly(diol ‐co‐ citrate)s as Novel Elastomeric Perivascular Wraps for the Reduction of Neointimal Hyperplasia
Author(s) -
Serrano M. Concepcion,
Vavra Ashley K.,
Jen Michele,
Hogg Melissa E.,
Murar Jozef,
Martinez Janet,
Keefer Larry K.,
Ameer Guillermo A.,
Kibbe Melina R.
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000509
Subject(s) - neointimal hyperplasia , reduction (mathematics) , elastomer , chemistry , medicine , surgery , restenosis , stent , organic chemistry , geometry , mathematics
The synthesis of poly(diol ‐co‐ citrate) elastomers that are biocompatible with vascular cells and can modulate the kinetics of the NO release based on the diol of selection is reported. NO‐mediated cytostatic or cytotoxic effects can be controlled depending on the NO dose and the exposure time. When implanted in vivo in a rat carotid artery injury model, these materials demonstrate a significant reduction of neointimal hyperplasia. This is the first report of a NO‐releasing polymer fabricated in the form of an elastomeric perivascular wrap for the treatment of neointimal hyperplasia. These elastomers also show promise for other cardiovascular pathologies where NO‐based therapies could be beneficial.