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Covalent Growth Factor Immobilization Strategies for Tissue Repair and Regeneration
Author(s) -
Masters Kristyn S.
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000505
Subject(s) - regeneration (biology) , biomaterial , tissue engineering , growth factor , covalent bond , chemistry , regenerative medicine , nanotechnology , biomedical engineering , microbiology and biotechnology , materials science , biochemistry , biology , engineering , organic chemistry , cell , receptor
Growth factors play a critical role in regulating processes involved in cellular differentiation and tissue regeneration, and are therefore considered essential elements in many tissue engineering strategies. The covalent immobilization of growth factors to biomaterial matrices addresses many of the challenges associated with delivering freely‐diffusible growth factors and has thus emerged as a promising method of achieving localized and sustained growth factor delivery. This Feature Article discusses methods that have been used to immobilize growth factors to substrates, followed by an overview of several tissue repair and regeneration applications in which immobilized growth factors have been used.