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Cell Specific Peptide‐Conjugated Polysaccharide Nanogels for Protein Delivery
Author(s) -
Shimoda Asako,
Sawada Shinichi,
Akiyoshi Kazunari
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000491
Subject(s) - nanogel , endocytosis , bovine serum albumin , chemistry , peptide , endosome , biophysics , drug delivery , biochemistry , cell , microbiology and biotechnology , biology , organic chemistry
A cell specific peptide (Arg‐Gly‐Asp; RGD)‐modified nanogel was prepared and evaluated for its potential to act as a protein delivery carrier. A bovine serum albumin (BSA)/RGD‐modified nanogel complex was efficiently internalized into cells through integrin‐mediated endocytosis. Endosomal escape of the RGD‐modified nanogel was observed after 24 h incubation. The nanogel proved useful for targeted protein delivery.