Cell Specific Peptide‐Conjugated Polysaccharide Nanogels for Protein Delivery | Zendy

Shimoda Asako | Zendy; Sawada Shinichi | Zendy; Akiyoshi Kazunari | Zendy

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Cell Specific Peptide‐Conjugated Polysaccharide Nanogels for Protein Delivery

Author(s) -

Shimoda Asako,

Sawada Shinichi,

Akiyoshi Kazunari

Publication year - 2011

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.201000491

Subject(s) - nanogel , endocytosis , bovine serum albumin , chemistry , peptide , endosome , biophysics , drug delivery , biochemistry , cell , microbiology and biotechnology , biology , organic chemistry

A cell specific peptide (Arg‐Gly‐Asp; RGD)‐modified nanogel was prepared and evaluated for its potential to act as a protein delivery carrier. A bovine serum albumin (BSA)/RGD‐modified nanogel complex was efficiently internalized into cells through integrin‐mediated endocytosis. Endosomal escape of the RGD‐modified nanogel was observed after 24 h incubation. The nanogel proved useful for targeted protein delivery.

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