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Enzyme‐Catalyzed Synthesis of a Novel Thermosensitive Polyester with Pendant Ketoprofen
Author(s) -
Wang HaiYang,
Zhou YuJie,
Wang Zao,
Wang Na,
Li Kun,
Yu XiaoQi
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000488
Subject(s) - polyester , ketoprofen , prodrug , copolymer , chemistry , catalysis , polymer chemistry , enzyme , peg ratio , organic chemistry , polymer , biochemistry , chromatography , finance , economics
A novel thermosensitive polyester with pendant ketoprofen was synthesized by copolymerization of PEG 800 with 2‐ketoprofendimethylmalate using CAL‐B at 70 °C. The products were characterized by NMR spectra and GPC. The in vitro study demonstrated that the polyester could release ketoprofen in physiological conditions, which indicates that the polyester could be a promising prodrug.