Enzyme‐Catalyzed Synthesis of a Novel Thermosensitive Polyester with Pendant Ketoprofen | Zendy

Wang HaiYang | Zendy; Zhou YuJie | Zendy; Wang Zao | Zendy; Wang Na | Zendy; Li Kun | Zendy; Yu XiaoQi | Zendy

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Enzyme‐Catalyzed Synthesis of a Novel Thermosensitive Polyester with Pendant Ketoprofen

Author(s) -

Wang HaiYang,

Zhou YuJie,

Wang Zao,

Wang Na,

Li Kun,

Yu XiaoQi

Publication year - 2011

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.201000488

Subject(s) - polyester , ketoprofen , prodrug , copolymer , chemistry , catalysis , polymer chemistry , enzyme , peg ratio , organic chemistry , polymer , biochemistry , chromatography , finance , economics

A novel thermosensitive polyester with pendant ketoprofen was synthesized by copolymerization of PEG 800 with 2‐ketoprofendimethylmalate using CAL‐B at 70 °C. The products were characterized by NMR spectra and GPC. The in vitro study demonstrated that the polyester could release ketoprofen in physiological conditions, which indicates that the polyester could be a promising prodrug.

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