Premium
The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose‐Derived Stromal Cells
Author(s) -
Kang SunWoong,
Cha ByungHyun,
Park Honghyun,
Park KwangSook,
Lee Kuen Yong,
Lee SooHong
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000479
Subject(s) - adipogenesis , adipose tissue , self healing hydrogels , chemistry , stromal cell , microbiology and biotechnology , biochemistry , polymer chemistry , cancer research , biology
The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD‐modified alginate hydrogels significantly stimulated FAK and integrin α1 gene expressions and vinculin expression in ASCs. In addition, RGD‐modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD‐modified alginate gels for adipose tissue regeneration.