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A Topographically Optimized Substrate with Well‐Ordered Lattice Micropatterns for Enhancing the Osteogenic Differentiation of Murine Mesenchymal Stem Cells
Author(s) -
Seo Chang Ho,
Furukawa Katsuko,
Suzuki Yuji,
Kasagi Nobuhide,
Ichiki Takanori,
Ushida Takashi
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000477
Subject(s) - mesenchymal stem cell , stem cell , cellular differentiation , substrate (aquarium) , chemistry , microbiology and biotechnology , biophysics , nanotechnology , materials science , biology , biochemistry , gene , ecology
Although recently a growing number of reports demonstrate that topography or geometry of the substrate also plays an important role in the fate of the stem cells, most of these studies are usually completed by a few distinct patterns such as simple lines, posts, etc. As a result, there is a lack of quantitative analysis of the relationship between topographical variation and the differentiation of stem cells. Here, the effectiveness of topography variation is studied systematically in several microengineered substrates on osteogenic differentiation. It is found that the effectiveness of the osteogenic differentiation has a peak around 3 µm in the interval length of micropatterns.