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Highly Efficient Intracellular Drug Delivery with a Negatively Charged Hyperbranched Polysulfonamine
Author(s) -
Chen Suyun,
Tan Zhonghua,
Li Nan,
Wang Ruibin,
He Lin,
Shi Yunfeng,
Jiang Lei,
Li Peiyong,
Zhu Xinyuan
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000473
Subject(s) - intracellular , cytotoxicity , doxorubicin , drug delivery , chemistry , biophysics , drug , in vitro , drug carrier , intracellular ph , distribution (mathematics) , biochemistry , combinatorial chemistry , pharmacology , biology , organic chemistry , chemotherapy , mathematical analysis , mathematics , genetics
Efficient intracellular translocation is achieved using an easily prepared hyperbranched polysulfonamine that remains negatively charged at physiological pH. Investigations on the cellular uptake mechanism and the subcellular distribution of PSA are reported. The in vitro cytotoxicity of PSA is found to be low. Using doxorubicin as a model drug, a PSA/drug complex is prepared by electrostatic interaction with a high drug payload that exhibits a controlled release in response to pH. Efficient intracellular drug delivery, strong growth inhibition of tumor cells, and low cytotoxicity to normal cells are observed. The results suggest a possible way to utilize anionic polymers for intracellular delivery of therapeutic moieties or drugs.