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Image Printing on the Surface of Anti‐Biofouling Zwitterionic Polymer Brushes by Ion Beam Irradiation
Author(s) -
Kitano Hiromi,
Suzuki Hisatomo,
Kondo Takuya,
Sasaki Kenta,
Iwanaga Shintaroh,
Nakamura Makoto,
Ohno Kohji,
Saruwatari Yoshiyuki
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000437
Subject(s) - polymer brush , adhesion , polystyrene , monomer , biofouling , brush , polymer chemistry , irradiation , polymer , materials science , polymerization , chemistry , adsorption , chemical engineering , composite material , organic chemistry , biochemistry , membrane , physics , nuclear physics , engineering
A CMB monomer was polymerized on a glass plate with a surface‐confined ATRP initiator containing a 2‐bromoisobutyryl group. The glass plate modified with a PCMB brush was highly hydrophilic and showed a strong resistance against non‐specific adsorption of proteins and cell adhesion. Upon ion beam irradiation, furthermore, the PCMB brush was ablated and a hollow space with a designed shape could be made to which HEK293 cells (from human embryonic kidney) and Hep G2 (from human hepatoma) cells non‐specifically adhered, while no adhesion of these cells to the non‐treated area on the brush was observed. The present results clearly indicate the usefulness of ion beam‐printed patterns of anti‐biofouling zwitterionic polymer brushes in the biomedical field.