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Synthesis and Antitumoral Activity of Gelatin/Polyoxometalate Hybrid Nanoparticles
Author(s) -
Guo Rui,
Cheng Yuan,
Ding Dan,
Li Xiaolin,
Zhang Leyang,
Jiang Xiqun,
Liu Baorui
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000434
Subject(s) - polyoxometalate , gelatin , nanoparticle , chemistry , chemical engineering , polymer , nanotechnology , materials science , combinatorial chemistry , organic chemistry , engineering , catalysis
Surfactant‐free gelatin/heptamolybdate (HM) hybrid nanoparticles are prepared by a simple and environmentally friendly approach utilizing the electrostatic interaction between anionic HM and the zwitterionic gelatin. The obtained nanoparticles have a tunable size and very high HM loading content up to about 70%. In vitro and in vivo experiments prove that the gelatin/HM hybrid nanoparticles exhibit significantly better antitumor activity than plain ammonium heptamolybdate solution. Therefore, the gelatin/HM hybrid nanoparticles reported here may serve as a prototype platform for polymer/polyoxometalate (POM) hybrid nanoparticles as cancer treatment agents and hence open up more opportunities to maximize the potential of POM‐based pharmaceutical agents.