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Self‐Assembly Strategy for the Preparation of Polymer‐Based Nanoparticles for Drug and Gene Delivery
Author(s) -
Chen Si,
Cheng SiXue,
Zhuo RenXi
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000427
Subject(s) - nanotechnology , drug delivery , polymer , nanoparticle , self assembly , gene delivery , materials science , targeted drug delivery , chemistry , biochemistry , genetic enhancement , composite material , gene
Nanoparticulate drug‐delivery systems have attained much importance because of their injectable property, the possibility to achieve passive targeting and active targeting, and unique advantages to realize stimuli tailored delivery. Molecular self‐assembly is a powerful method for fabricating polymer‐based nanoparticles, which involves various driving forces, such as hydrophobic interactions, electrostatic interactions, stereocomplexation, host/guest interactions and hydrogen bonding. By fine tuning one or many types of these interactions, self‐assemblies with a wide range of structures and functions could be fabricated. In this article, recent developments in different self‐assembly strategies for the preparation of polymer‐based nanoparticulate delivery systems are discussed.