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Modulation of Material Properties of a Decellularized Myocardial Matrix Scaffold
Author(s) -
Singelyn Jennifer M.,
Christman Karen L.
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000423
Subject(s) - decellularization , scaffold , biomedical engineering , chemistry , extracellular matrix , matrix (chemical analysis) , myocardial infarction , biophysics , materials science , cardiology , medicine , biochemistry , chromatography , biology
Injectable materials offer the potential for minimally invasive therapy for myocardial infarction (MI), either as an acellular scaffold or as a cell delivery vehicle. A recently developed myocardial matrix hydrogel, derived from decellularized porcine ventricular tissue, has the potential to aid in cardiac repair following an MI. Herein, we set out to study the effects of cross‐linking on the cardiac hydrogel stiffness, degradation properties, cellular migration, and catheter injectability in vitro. Cross‐linking increased stiffness, while slowing degradation and cellular migration through the gels. Additionally, the cross‐linked material was pushed through a clinically relevant catheter. These results demonstrate that the material properties of myocardial matrix can be tuned via cross‐linking, while maintaining appropriate viscosity for catheter injectability.