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Polyaspartamide ‐graft‐ Polymethacrylate Nanoparticles for Doxorubicin Delivery
Author(s) -
Licciardi Mariano,
Cavallaro Gennara,
Di Stefano Mauro,
Fiorica Calogero,
Giammona Gaetano
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000399
Subject(s) - zeta potential , nanoparticle , chemistry , drug delivery , dynamic light scattering , copolymer , polymer chemistry , cytotoxicity , protonation , doxorubicin , polyacrylic acid , microparticle , aqueous solution , carboxylic acid , nuclear chemistry , biophysics , polymer , chemical engineering , nanotechnology , materials science , organic chemistry , in vitro , biochemistry , ion , surgery , chemotherapy , engineering , biology , medicine
A new PHEA‐IB‐PMANa + copolymer has been synthesized and its pH‐induced self‐assembly has been investigated in an aqueous medium. PHEA‐IB‐PMANa + formed nanoparticles with diameters from 25 to 50 nm upon protonation of the carboxylic acid moieties dislocated along the grafted polymethacrylate sodium salt side chains. The physico‐chemical characterization of the nanoparticles was performed using light scattering, zeta‐potential measurements, SEM, and AFM. Doxorubicin‐loaded nanoparticles were prepared and drug release profiles were evaluated under conditions mimicking physiological media. A biological characterization was carried out by testing the cytotoxicity on Caco‐2 cells, and cellular uptake on mouse monocyte macrophage (J774 A.1) and Caco‐2 cells.