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Low Thrombogenicity Coating of Nonwoven PET Fiber Structures for Vascular Grafts
Author(s) -
Dimitrievska Sashka,
Maire Marion,
DiazQuijada Gerardo A.,
Robitaille Lucie,
Ajji Abdellah,
Yahia L'Hocine,
Moreno Maria,
Merhi Yahye,
Bureau Martin N.
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000390
Subject(s) - thrombogenicity , platelet activation , surface modification , biomedical engineering , coating , platelet , platelet adhesion , materials science , adhesion , chemistry , composite material , medicine , immunology
Vascular PET grafts (Dacron) have shown good performance in large vessels (≥6 mm) applications. To address the urgent unmet need for small‐diameter (2–6 mm) vascular grafts, proprietary high‐compliance nonwoven PET fiber structures were modified with various PEG concentrations using PVA as a cross‐linking agent, to fabricate non‐thrombogenic mechanically compliant vascular grafts. The blood compatibility assays measured through platelet adhesion (SEM and mepacrine dye) and platelet activation (morphological changes, P‐selectin secretion, and TXB2 production) demonstrate that functionalization using a 10% PEG solution was sufficient to significantly reduce platelet adhesion/activation close to optimal literature‐reported levels observed on carbon‐coated ePTFE.