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Porous Scaffolds Based on Cross‐Linking of Poly( L ‐glutamic acid)
Author(s) -
Cao Bin,
Yin Jingbo,
Yan Shifeng,
Cui Lei,
Chen Xuesi,
Xie Yongtao
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000389
Subject(s) - porosity , swelling , plga , chemical engineering , polymer , scaffold , tissue engineering , chemistry , polymer chemistry , materials science , in vitro , composite material , biomedical engineering , biochemistry , medicine , engineering
Porous scaffolds based on water‐soluble PLGA and CS were prepared. The pores were verified to be alveolate, uniform and continuous. The effects of freezing temperature, freeze‐drying time, solid content and molecular weight of reactants on the pore structure of the scaffolds were studied. The scaffold morphology could be adjusted by changing the freezing temperature and solid content of reacting polymer. Their degradation rate can be adjusted by changing the proportion of PLGA and CS. The porosity of scaffolds was higher than 90% and the high swelling ratio showed that these scaffolds had excellent hydrophilic performance. The in vitro culture of chondrocytes indicates that the obtained PLGA/CS porous scaffolds are very promising biomaterials for tissue engineering applications.