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Poly(ester urethane) Guides for Peripheral Nerve Regeneration
Author(s) -
Chiono Valeria,
Sartori Susanna,
Rechichi Alfonsina,
TondaTuro Chiara,
Vozzi Giovanni,
Vozzi Federico,
D'Acunto Mario,
Salvadori Claudia,
Dini Francesca,
Barsotti Giovanni,
Carlucci Fabio,
Burchielli Silvia,
Nicolino Silvia,
Audisio Chiara,
Perroteau Isabelle,
Giusti Paolo,
Ciardelli Gianluca
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000354
Subject(s) - regeneration (biology) , gelatin , in vivo , in vitro , chemistry , adhesion , sciatic nerve , elastomer , peripheral nerve , biomedical engineering , polymer chemistry , biophysics , materials science , anatomy , microbiology and biotechnology , biochemistry , organic chemistry , biology , medicine
Abstract A biocompatible and elastomeric PU was synthesized from low‐molecular‐weight PCL as macrodiol, CMD as chain extender and HDI as chain linker for applications in the field of peripheral nerve repair. PU cast films supported in vitro attachment and proliferation of NOBEC. The in vitro adhesion and proliferation of S5Y5 neuroblastoma cells on the inner surface of uncoated, gelatin‐ and PL‐coated PU guides were compared. Due to their superior in vitro performance, PL‐coated PU guides were tested in vivo for the repair of 1.8 cm‐long defects in rat sciatic nerves. The progressive regeneration was confirmed by EMG and histological analysis showing the presence of regenerating fibers in the distal stumps.