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Design and Synthesis of Novel Polyglycerol Hybrid Nanomaterials for Potential Applications in Drug Delivery Systems
Author(s) -
Zarrabi Ali,
Adeli Mohsen,
Vossoughi Manouchehr,
Shokrgozar Mohammad Ali
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000336
Subject(s) - nanomaterials , drug delivery , nanomedicine , nanotechnology , chemistry , biocompatible material , drug carrier , targeted drug delivery , hybrid material , solubility , nanoparticle , combinatorial chemistry , materials science , organic chemistry , biomedical engineering , medicine
The synthesis of a new drug delivery system based on hybrid nanomaterials containing a β ‐CD core and hyperbranched PG is described. Conjugating PG branches onto β ‐CD not only increases its water solubility but also affects its host/guest properties deeply. It can form molecular inclusion complexes with small hydrophobic guest molecules such as ferrocene or FITC with reasonable release. In addition, the achievable payloads are significantly higher as for carriers such as hyperbranched PGs. Short‐term in vitro cytotoxicity and hemocompatibility tests on L929 cell lines show that the hybrid nanomaterial is highly biocompatible. Due to their outstanding properties, β ‐CD ‐g‐ PG hybrid nanomaterials are introduced as promising materials for nanomedicine, e.g., for drug delivery issues.