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Novel Polymeric Vesicles with pH‐Induced Deformation Character for Advanced Drug Delivery
Author(s) -
Zheng Cheng,
Yao Xiaping,
Qiu Liyan
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000333
Subject(s) - polyphosphazene , vesicle , amphiphile , chemistry , drug delivery , macromolecule , biophysics , drug carrier , aqueous solution , copolymer , membrane , organic chemistry , polymer , biochemistry , biology
pH‐Responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH‐sensitive DPA were successfully synthesized and characterized. The copolymer can self‐assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lipophilic and hydrophilic molecules. The pH‐dependent structure change of vesicles was also observed by DLS and TEM. Dox‐loaded vesicles exhibit a sharp pH‐responsive drug release profile and dramatically enhance the cytotoxicity of Dox against Dox‐resistant MCF‐7/adr cells. These results suggest such vesicles based on pH‐responsive polyphosphazene hold great potential for specific drug therapy.