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Synthesis of Water Soluble, Biodegradable, and Electroactive Polysaccharide Crosslinker with Aldehyde and Carboxylic Groups for Biomedical Applications
Author(s) -
Wang Qian,
He Wen,
Huang Junqi,
Liu Siwei,
Wu Guifu,
Teng Wei,
Wang Qinmei,
Dong Yugang
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000256
Subject(s) - copolymer , self healing hydrogels , aldehyde , gelatin , chemistry , drug delivery , grafting , polymer chemistry , polysaccharide , combinatorial chemistry , organic chemistry , polymer , catalysis
We report the synthesis and characterization of a polysaccharide crosslinker of tetraaniline grafting oxidized sodium alginate with large aldehyde and carboxylic groups. We demonstrate that this copolymer has the following properties: it is water soluble under any pH, biodegradable, electroactive, and noncytotoxic; it can self‐assemble into nanoparticles with large active functional groups on the outer surface; it can crosslink materials with amino and aminoderivative groups like gelatin to form hydrogels, and thus the electroactivity is readily introduced to the materials. This copolymer has potential applications in biomedical fields such as tissue engineering, drug delivery, and nerve probes where electroactivity is required.