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Electrospun Functionalized Polyaniline Copolymer‐Based Nanofibers with Potential Application in Tissue Engineering
Author(s) -
GizdavicNikolaidis Marija,
Ray Sudip,
Bennett Jared R.,
Easteal Allan J.,
Cooney Ralph P.
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000237
Subject(s) - nanofiber , electrospinning , biocompatibility , copolymer , tissue engineering , materials science , polymer chemistry , aniline , chemical engineering , dimethyl sulfoxide , chitosan , polymer , chemistry , nanotechnology , composite material , organic chemistry , biomedical engineering , medicine , engineering , metallurgy
Nanofibrous blends of HCl‐doped poly(aniline‐ co ‐3‐aminobenzoic acid) (3ABAPANI) copolymer and poly(lactic acid) (PLA) were fabricated by electrospinning solutions of the polymers, in varying relative proportions, in dimethyl sulfoxide/tetrahydrofuran mixture. The morphology, mechanical and electrical properties of the nanofibers were characterized and an assessment of their bioactivity performed. To assess cell morphology and biocompatibility, pure PLA and 3ABAPANI‐PLA nanofibrous mats were deposited in the form of three‐dimensional networks with a high degree of connectivity, on glass substrates, and their ability to promote proliferation of COS‐1 fibroblast cells was determined. The nanofibrous electrospun 3ABAPANI‐PLA blends gave enhanced cell growth, potent antimicrobial capability against Staphylococcus aureus and electrical conductivity. This new class of nanofibrous blends can potentially be employed as tissue engineering scaffolds, and in particular have showed promise as the basis of a new generation of functional wound dressings that may eliminate deficiencies of currently available antimicrobial dressings.