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Bioactive Scaffolds for Engineering Vascularized Cardiac Tissues
Author(s) -
Chiu Loraine L. Y.,
Radisic Milica,
VunjakNovakovic Gordana
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000202
Subject(s) - biomaterial , tissue engineering , context (archaeology) , cardiac function curve , cardiac muscle , biomedical engineering , function (biology) , chemistry , microbiology and biotechnology , cardiology , medicine , anatomy , heart failure , biology , paleontology
Functional vascularization is a key requirement for the development and function of most tissues, and most critically cardiac muscle. Rapid and irreversible loss of cardiomyocytes during cardiac infarction directly results from the lack of blood supply. Contractile cardiac grafts, engineered using cardiovascular cells in conjunction with biomaterial scaffolds, are an actively studied method for cardiac repair. In this article, we focus on biomaterial scaffolds designed to mediate the development and maturation of vascular networks, by immobilized growth factors. The interactive effects of multiple vasculogenic factors are discussed in the context of cardiac tissue engineering.