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Bioresorbable Electrospun Fibers for Immobilization of Thiol‐Containing Compounds
Author(s) -
Lösel Robert,
Grafahrend Dirk,
Möller Martin,
Klee Doris
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000101
Subject(s) - electrospinning , thiol , surface modification , protein adsorption , chemistry , adsorption , peg ratio , tissue engineering , fiber , chemical engineering , polymer chemistry , polymer , biomedical engineering , organic chemistry , medicine , finance , economics , engineering
For the reconstruction of functional tissue, biodegradable scaffolds providing specific surface functionality and a three‐dimensional structure matching that of the damaged tissue are needed. Fibers capable of controlling cell‐fiber interaction were produced by electrospinning of PDLLA ‐block‐ PEG with thiol‐reactive end groups from a solvent mixture. The hydrophilic fibers uniquely combine minimized non‐specific protein adsorption and well‐defined surface reactivity allowing controlled immobilization of peptides and proteins. Human dermal fibroblasts show adherence and proliferation on the surface of RGDC‐functionalized electrospun PDLLA ‐block‐ PEG fibers.