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Poly( β ‐cyclodextrin)/Curcumin Self‐Assembly: A Novel Approach to Improve Curcumin Delivery and its Therapeutic Efficacy in Prostate Cancer Cells
Author(s) -
Yallapu Murali Mohan,
Jaggi Meena,
Chauhan Subhash C.
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000084
Subject(s) - curcumin , du145 , chemistry , flow cytometry , prostate cancer , prostate , cancer cell , cancer , confocal microscopy , cancer research , medicine , microbiology and biotechnology , biochemistry , biology , lncap
A novel PCD/CUR self‐assembly approach for improved curcumin delivery to prostate cancer cells is described. The formation of PCD/CUR was confirmed using FTIR, DSC, TGA, and SEM/TEM, and their stability and solubility under physiological conditions was demonstrated. A mechanism for self‐assembly is proposed. Intracellular uptake of the self‐assemblies was studied by flow cytometry and immunofluorescence microscopy. The therapeutic efficacy was determined by cell proliferation and colony formation assays using C4‐2, DU145 and PC3 prostate cancer cells. The results suggest that the PCD/CUR formulation could be a useful system for improving curcumin delivery and its therapeutic efficacy in prostate cancer.