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Progress in Depsipeptide‐Based Biomaterials
Author(s) -
Feng Yakai,
Lu Jian,
Behl Marc,
Lendlein Andreas
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000076
Subject(s) - copolymer , polymer , depsipeptide , materials science , chemistry , biodegradation , polymer science , nanotechnology , polymer chemistry , organic chemistry , stereochemistry
Polydepsipeptides – alternating copolymers of an α‐amino acid and an α‐hydroxy acid – are a group of biodegradable polymers. Versatile polydepsipeptides with or without pendant functional groups, as well as various polymer architectures, for example, providing alternative, random, diblock, triblock, multiblock or graft sequence structures, can be synthesized via ring‐opening copolymerization of various morpholine‐2,5‐dione derivatives. They are potential candidates for a wide range of biomedical applications. Polydepsipeptides are described in this review from the aspect of materials science, especially as biomaterials. We mainly focus on various techniques developed to synthesize polydepsipeptides and their copolymers, biodegradation behaviors, shape‐memory properties and possible biomedical applications.