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Influence of Solute Charge and Hydrophobicity on Partitioning and Diffusion in a Genetically Engineered Silk‐Elastin‐Like Protein Polymer Hydrogel
Author(s) -
Dinerman Adam A.,
Cappello Joseph,
ElSayed Mohamed,
Hoag Stephen W.,
Ghandehari Hamidreza
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000061
Subject(s) - self healing hydrogels , chemistry , dendrimer , polymer , diffusion , silk , polymer chemistry , biophysics , drug delivery , chemical engineering , materials science , organic chemistry , thermodynamics , physics , biology , engineering , composite material
The influence of solute hydrophobicity and charge on partitioning and diffusion in physically crosslinked networks of a genetically engineered SELP polymer was investigated. A series of fluorescent dyes were used to assess the impact of solute charge and hydrophobicity on release behavior. The mechanism of solute release from the SELP hydrogel appeared to vary as a function of dye hydrophobicity. The extent of FITC attachment to amine‐terminated G4 dendrimers influenced SELP hydrogel partitioning more than dendrimer diffusion properties. Results suggest the possibility of controlling solute release from SELP hydrogels by modifying the hydrophobicity and surface charge of drugs and drug/polymer conjugates as well as the possibility of “designing‐in” solute‐specific interactions.