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Tuning Cell Adhesion by Incorporation of Charged Silicate Nanoparticles as Cross‐Linkers to Polyethylene Oxide
Author(s) -
Schexnailder Patrick J.,
Gaharwar Akhilesh K.,
Bartlett II Rush L.,
Seal Brandon L.,
Schmidt Gudrun
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000053
Subject(s) - nanocomposite , biomaterial , adhesion , silicate , materials science , cell adhesion , chemical engineering , nanoparticle , polyethylene , oxide , surface modification , chemistry , nanotechnology , composite material , engineering , metallurgy
Controlling cell adhesion on a biomaterial surface is associated with the long‐term efficacy of an implanted material. Here we connect the material properties of nanocomposite films made from PEO physically cross‐linked with layered silicate nanoparticles (Laponite) to cellular adhesion. Fibroblast cells do not adhere to pure PEO, but they attach to silicate containing nanocomposites. Under aqueous conditions, the films swell and the degree of swelling depends on the nanocomposite composition and film structure. Higher PEO compositions do not support cell proliferation due to little exposed silicate surfaces. Higher silicate compositions do allow significant cell proliferation and spreading. These bio‐nanocomposites have potential for the development of biomedical materials that can control cellular adhesion.