Premium
Characterization of Ultra‐Thin Temperature‐Responsive Polymer Layer and Its Polymer Thickness Dependency on Cell Attachment/Detachment Properties
Author(s) -
Fukumori Kazuhiro,
Akiyama Yoshikatsu,
Kumashiro Yoshikazu,
Kobayashi Jun,
Yamato Masayuki,
Sakai Kiyotaka,
Okano Teruo
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000043
Subject(s) - polymer , materials science , characterization (materials science) , adhesion , layer (electronics) , adsorption , polymer chemistry , chemical engineering , composite material , nanotechnology , chemistry , engineering
Ultra thin poly( N ‐isopropylacrylamide) (PIPAAm) modified glass coverslips (PIAPAm‐CS) using electron beam irradiation exhibited a clear relationship between the polymer thickness and thermal cell adhesion/detachment behavior. The polymer thickness dependency and the characteristic of ultra thin PIPAAm layer, has been illustrated in terms of the molecular motion of the modified PIPAAm chains. PIPAAm‐CSs surfaces with various area‐polymer densities and thicknesses were characterized by AFM and protein adsorption assay. The newly obtained results gave a further insight into the illustration. Finally, the future application of intelligent surfaces was discussed for fabricating tissue and organ.