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Biodegradable and Electroactive TEMPO‐Substituted Acrylamide/Lactide Copolymers
Author(s) -
Zhuang Xiuli,
Zhang Han,
Chikushi Natsuru,
Zhao Changwen,
Oyaizu Kenichi,
Chen Xuesi,
Nishide Hiroyuki
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201000031
Subject(s) - copolymer , macromonomer , polymer chemistry , moiety , peroxide , chemistry , lactide , fourier transform infrared spectroscopy , benzoyl peroxide , polymerization , polymer , organic chemistry , chemical engineering , engineering
Copolymers composed of PLA and PTAm were prepared by a macromonomer approach. The PLA bearing vinyl group at chain end was copolymerized with 2,2,6,6‐tetrametylpiperidine‐4‐ylacrylamide. The resulted copolymers were oxidized by a peroxide to give PTAm‐ g ‐PLA. The structures of the copolymers were confirmed by NMR and FTIR spectroscopy. The comparison of 1 H NMR results and SQUID measurements demonstrated that the oxidation of the PTAm fragment proceeded almost to completion. An MTT assay, cell adhesion and spreading evaluation showed that the copolymers exhibited improved cytocompatibility as compared to the PTAm homopolymer due to the introduction of the biocompatible PLA moiety.