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Development of Electrospun Three‐arm Star Poly( ε ‐caprolactone) Meshes for Tissue Engineering Applications
Author(s) -
Puppi Dario,
Detta Nicola,
Piras Anna Maria,
Chiellini Federica,
Clarke David A.,
Reilly Gwendolen C.,
Chiellini Emo
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900422
Subject(s) - caprolactone , tissue engineering , ultimate tensile strength , materials science , adhesion , electrospinning , polymer , copolymer , morphology (biology) , composite material , biomedical engineering , chemical engineering , biology , genetics , medicine , engineering
We have developed three‐dimensional electrospun microfibrous meshes of a novel star branched three‐arm poly( ε ‐caprolactone) (*PCL) as potential scaffolds for tissue engineering applications. The processing conditions required to obtain uniform fibers were optimized by studying their influence on fiber morphology and size. Polymer molecular weight and solution feed rate influenced both the mesh microstructure and the tensile properties of the developed mats. Electrospun samples were also tested for their mechanical properties in wet conditions, showing higher yield strength and strain in comparison to that observed in dry conditions. Cell culture experiments employing MC3T3‐E1 osteoblast like cells showed good cell viability adhesion and collagen production on the *PCL scaffolds.