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Surface Segregation Assessment In Poly( ε ‐caprolactone)‐poly(ethylene glycol) Multiblock Copolymer Films
Author(s) -
Cometa Stefania,
Chiellini Federica,
Bartolozzi Irene,
Chiellini Emo,
De Giglio Elvira,
Sabbatini Luigia
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900284
Subject(s) - copolymer , ethylene glycol , materials science , chemical engineering , wetting , peg ratio , polymer chemistry , x ray photoelectron spectroscopy , adhesion , solvent , casting , surface modification , polymer , chemistry , composite material , organic chemistry , finance , engineering , economics
The ability to predict the in vivo performance of multiblock‐copolymer‐based biomaterials is crucial for their applicability in the biomedical field. In this work, XPS analysis of PCL‐PEG copolymers was carried out, as well as morphological and wettability evaluations by SEM and CA measurements, respectively. XPS analysis on films equilibrated in PBS demonstrated a further enrichment in the PEG component on the surface. Copolymer films obtained by casting using different solvents showed a dependence in segregation according to the solvent employed. Cell adhesion tests demonstrated the importance of copolymer segregation and rearrangement in a wet environment, with a dependence of these phenomena on the copolymer molecular weight.