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Electrospun Silk Material Systems for Wound Healing
Author(s) -
Wharram Scott E.,
Zhang Xiaohui,
Kaplan David L.,
McCarthy Stephen P.
Publication year - 2010
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900274
Subject(s) - silk , biomaterial , wound dressing , wound healing , biocompatible material , absorption of water , chemistry , materials science , polymer science , biomedical engineering , chemical engineering , polymer chemistry , composite material , nanotechnology , surgery , medicine , engineering
The functional properties of six distinct electrospun silk material groups were evaluated to assess conformational and biocompatible characteristics related to wound dressings. In a hydrated state, all six silk matrices exhibited absorption, water vapor transmission, oxygen permeation and enzymatic biodegradation suitable for full‐thickness wound sites. Employing constrained drying techniques, silk concentration was a determinate factor influencing material structural properties related to the storage and distribution of such wound dressing systems. Subsequently, three electrospun silk models demonstrated ideal biomaterial properties with potential utility for wound dressings.