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Recent Progress in Polyphosphoesters: From Controlled Synthesis to Biomedical Applications
Author(s) -
Wang YuCai,
Yuan YouYong,
Du JinZhi,
Yang XianZhu,
Wang Jun
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900253
Subject(s) - biocompatibility , biocompatible material , chemistry , phosphodiester bond , hydrolytic degradation , nanotechnology , copolymer , hydrolysis , polymer , polymer science , materials science , organic chemistry , biochemistry , biomedical engineering , medicine , rna , gene
Polyphosphoesters (PPEs) with repeating phosphoester bonds in the backbone are structurally versatile, biocompatible, and biodegradable through hydrolysis as well as enzymatic digestion under physiological conditions. They are appealing for biological applications because of their potential functionality, biocompatibility, and similarity to biomacromolecules such as nucleic acids. The expanding scope of PPEs in materials science, especially as biomaterials, is described in this review. We mainly focus on controlled synthetic methods of PPEs, which provide access to novel and complex polymer structures, especially for block copolymers. The hydrolytic and enzymatic degradation of PPEs, thermoresponsive PPEs, and biomedical applications have also been discussed.