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Biodegradable Polymeric Microcarriers with Controllable Porous Structure for Tissue Engineering
Author(s) -
Shi Xudong,
Sun Lei,
Jiang Jian,
Zhang Xiaolin,
Ding Wenjun,
Gan Zhihua
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900224
Subject(s) - microcarrier , tissue engineering , porosity , chemical engineering , polymer science , biomaterial , biofouling , polymer chemistry , chemistry , materials science , nanotechnology , composite material , biomedical engineering , membrane , engineering , biochemistry , cell
Porous microspheres fabricated by biodegradable polymers show great potential as microcarriers for cell cultivation in tissue engineering. Herein biodegradable poly( DL ‐lactide) (PLA) was used to fabricate porous microspheres through a modified double emulsion solvent evaporation method. The influence of fabrication parameters, such as the stirring speed of the primary and secondary emulsion, the polymer concentration of the oil phase, and solvent type, as well as the post‐hydrolysis treatment of the porous structure of the PLA microspheres are discussed. Good attachment and an active spread of MG‐63 cells on the microspheres is observed, which indicates that the PLA microspheres with controllable porous structure are of great potential as cell delivery carriers for tissue engineering.