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Amphiphilic Polymer Nanoparticles: Characterization and Assessment as New Drug Carriers
Author(s) -
Dutta Pranabesh,
Shrivastava Saurabh,
Dey Joykrishna
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900135
Subject(s) - aqueous solution , copolymer , amphiphile , chemistry , nanoparticle , micelle , polymer chemistry , polymer , chemical engineering , organic chemistry , materials science , nanotechnology , engineering
An amino‐acid‐based hydrophobically modified biocompatible copolymer, poly[(sodium N ‐acryloyl‐ L ‐valinate) ‐co‐ ( N ‐octylacrylamide)] was synthesized and characterized. Techniques such as fluorescence probes, DLS, and TEM were used to investigate its aggregation behavior in aqueous solution. The copolymer was observed to form micellar aggregates having diameters in the nanometer range in aqueous solution (pH = 8) through inter‐chain hydrophobic association. This behavior was found to be similar to that of poly[(sodium N ‐acryloyl‐ L ‐valinate) ‐co‐ ( N ‐dodecylacrylamide)]. The compact micellar nanostructures were observed to be stable with respect to changes of pH and temperature. The encapsulation and release of griseofulvin, a hydrophobic model drug, was studied.