Hyperbranched Polyamidoamines Containing β ‐Cyclodextrin for Controlled Release of Chlorambucil

This work is focused on the controlled drug release behavior of hyperbranched HPMA in the presence of β ‐CD. Hence, three HPMA‐ β ‐CDs and a pure HPMA were synthesized by Michael addition polymerization. As a model drug, CLB (an anti‐cancer drug) was loaded into them via a solution method for in vitro release studies. The DSC results indicate that the CLB/polymer interactions are at the molecular level. Loading CLB into these polymers results in an evident increase in their glass transition temperatures, and Δ T g depends on the β ‐CD content. The controlled‐release experiments show that the presence of β ‐CD can appropriately slow the release of CLB from HPMA‐ β ‐CDs and adjust the ratio of CLB released in total drug loading.