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Hyperbranched Polyamidoamines Containing β ‐Cyclodextrin for Controlled Release of Chlorambucil
Author(s) -
Zhou Yuanyuan,
Guo Zhe,
Zhang Yongwen,
Huang Wei,
Zhou Yongfeng,
Yan Deyue
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900110
Subject(s) - chemistry , polymer , cyclodextrin , polymerization , controlled release , glass transition , drug , beta cyclodextrins , chlorambucil , beta (programming language) , polymer chemistry , chemical engineering , organic chemistry , pharmacology , medicine , surgery , chemotherapy , cyclophosphamide , computer science , engineering , programming language
This work is focused on the controlled drug release behavior of hyperbranched HPMA in the presence of β ‐CD. Hence, three HPMA‐ β ‐CDs and a pure HPMA were synthesized by Michael addition polymerization. As a model drug, CLB (an anti‐cancer drug) was loaded into them via a solution method for in vitro release studies. The DSC results indicate that the CLB/polymer interactions are at the molecular level. Loading CLB into these polymers results in an evident increase in their glass transition temperatures, and Δ T g depends on the β ‐CD content. The controlled‐release experiments show that the presence of β ‐CD can appropriately slow the release of CLB from HPMA‐ β ‐CDs and adjust the ratio of CLB released in total drug loading.