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The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol‐ block ‐( ε ‐caprolactone)] Copolymers
Author(s) -
Mao Jing,
Gan Zhihua
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900104
Subject(s) - copolymer , glycidol , amphiphile , chemistry , polymer chemistry , micelle , pyrene , polymersome , ring opening polymerization , caprolactone , polymerization , raft , drug delivery , biodegradation , organic chemistry , polymer , aqueous solution , catalysis
An amphiphilic diblock copolymer PG‐ b ‐PCL with well‐controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring‐opening polymerization. The micellization and drug release of PG‐ b ‐PCL copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. The biodegradation of PG‐ b ‐PCL copolymers was studied with microspheres as research samples. It has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic PG block in PG‐ b ‐PCL copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres.