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Thermoresponsive, Hydrolytically Degradable Polymer Micelles Intended for Radionuclide Delivery
Author(s) -
Hruby Martin,
Konak Cestmir,
Kucka Jan,
Vetrik Miroslav,
Filippov Sergey K.,
Vetvicka David,
Mackova Hana,
Karlsson Goran,
Edwards Katarina,
Rihova Blanka,
Ulbrich Karel
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900083
Subject(s) - methacrylamide , micelle , copolymer , polymer , aqueous solution , dynamic light scattering , chemistry , polymer chemistry , lower critical solution temperature , drug delivery , self healing hydrogels , materials science , organic chemistry , nanotechnology , nanoparticle , acrylamide
Abstract Novel polymer micelles, prepared by self‐assembling thermoresponsive poly( N ‐isopropylacrylamide) ‐graft‐ poly[ N ‐(2‐hydroxypropyl)methacrylamide] copolymers with hydrolytically degradable N ‐glycosylamine groups between the polymer blocks are proposed for delivery of diagnostic and therapeutic radionuclides into solid tumors. The micelles are formed by fast heating of an aqueous solution of the copolymer to 37 °C. They have a hydrodynamic diameter of 128 nm (measured using dynamic light scattering) and slowly degrade during incubation in aqueous buffer at pH = 7.4. Labeling with both 131 I and 90 Y proceeds with high yields (>85%). The unlabeled polymers are not cytotoxic for any of the tested murine and human cell lines.