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A Hybrid DNA Aptamer–Dendrimer Nanomaterial for Targeted Cell Labeling
Author(s) -
Zhou Jing,
Soontornworajit Boonchoy,
Martin Jacob,
Sullenger Bruce A.,
Gilboa Eli,
Wang Yong
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900046
Subject(s) - aptamer , dendrimer , nanomaterials , nucleic acid , chemistry , dna , nanotechnology , microbiology and biotechnology , biochemistry , materials science , biology
Antibodies are natural nanomaterials and have been widely used for targeted cell labeling. However, the applications of antibodies are often limited by their large size and instability. The purpose of this study is to develop a new type of multifunctional nanomaterial that is comprised of a nucleic acid aptamer and a dendrimer, both of which are stable. This nanomaterial is ≈8 nm in size. Moreover, it could not only carry multiple signal molecules, but also bind to target cancer cells with high affinity and specificity. This sub‐10 nm multifunctional nanomaterial is expected to be useful in basic biomedical research and clinical medicine.