Premium
Dual‐Responsive Supramolecular Hydrogels from Water‐Soluble PEG‐Grafted Copolymers and Cyclodextrin
Author(s) -
Ren Lixia,
He Lihong,
Sun Tongchen,
Dong Xia,
Chen Yongming,
Huang Jin,
Wang Chun
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200900021
Subject(s) - self healing hydrogels , copolymer , cyclodextrin , chemistry , aqueous solution , polymer chemistry , peg ratio , drug delivery , chemical engineering , kinetics , supramolecular chemistry , drug carrier , controlled release , organic chemistry , molecule , polymer , physics , finance , quantum mechanics , engineering , economics
Novel temperature and pH dual‐responsive hydrogels were constructed by inclusion of poly(PEGMA) ‐co‐ poly(DMA) with α ‐cyclodextrin in aqueous solution. The temperature‐ or pH‐induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual‐responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery.