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Therapeutic Efficacy of 2‐Methoxyestradiol Microcrystals Encapsulated within Polyelectrolyte Multilayers
Author(s) -
Wang Su He,
Shi Xiangyang,
Chen Xisui,
Baker James R.
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800381
Subject(s) - polyelectrolyte , bioavailability , 2 methoxyestradiol , chemistry , nanotechnology , solubility , biophysics , drug , viability assay , drug carrier , drug delivery , chemical engineering , materials science , cell , polymer , organic chemistry , pharmacology , biochemistry , in vitro , medicine , engineering , biology
Development of a novel formulation of anticancer drugs to improve their water‐solubility and bioavailability remains a great challenge. Herein, the potential anticancer agent 2‐methoxyestradiol (2‐ME) was selected as a model drug and was encapsulated within polyelectrolyte (PE) multilayers by layer‐by‐layer deposition of oppositely charged PEs onto the drug microcrystal surfaces. Cell viability and morphology observation of two cell lines reveal that the PE multilayer‐encapsulated 2‐ME microcrystals markedly decrease the cell viability, displaying similar inhibitory effect to that of the conventional formulation of 2‐ME dissolved in ethanol. The current approach to encapsulate hydrophobic drug microparticles may be useful for formulating different drugs for a variety of biological applications.