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Thermosensitive Micelles Based on Folate‐Conjugated Poly( N ‐vinylcaprolactam) ‐block‐ Poly(ethylene glycol) for Tumor‐Targeted Drug Delivery
Author(s) -
Prabaharan Mani,
Grailer Jamison J.,
Steeber Douglas A.,
Gong Shaoqin
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800366
Subject(s) - micelle , chemistry , ethylene glycol , cytotoxicity , peg ratio , conjugated system , copolymer , drug delivery , biophysics , endocytosis , drug carrier , aqueous solution , biochemistry , polymer , in vitro , organic chemistry , cell , finance , economics , biology
Thermosensitive PNVCL‐ b ‐PEG block copolymer coupled with folic acid was prepared as an anti‐cancer drug carrier. This polymer self‐assembled into stable micelles in aqueous solutions at above 33 °C. At 37 °C, the release profile of PNVCL‐ b ‐PEG‐FA micelles showed a slower and more controlled release of the entrapped 5‐FU than that at 25 °C. The blank and 5‐FU‐loaded PNVCL‐ b ‐PEG‐FA micelles did not induce remarkable cytotoxicity against the EA.hy 926 human endothelial cell line; however, 5‐FU‐loaded PNVCL‐ b ‐PEG‐FA micelles showed a cytotoxicity effect against 4T1 mouse mammary carcinoma cells due to the availability of loaded anti‐cancer drugs delivered to the inside of the cancer cells by the folate‐receptor‐mediated endocytosis process.