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Characterization of Star Adhesive Sealants Based On PEG/Dextran Hydrogels
Author(s) -
Artzi Natalie,
Shazly Tarek,
Crespo Cristina,
Ramos Adriana Bon,
Chenault H. Keith,
Edelman Elazer R.
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800355
Subject(s) - dextran , biocompatibility , adhesive , self healing hydrogels , peg ratio , cyanoacrylate , chemistry , adhesion , chemical engineering , materials science , biomedical engineering , polymer chemistry , composite material , organic chemistry , finance , layer (electronics) , engineering , economics , medicine
Swellable PEG amine/dextran aldehyde composite materials are emerging as a controlled, biocompatible tissue adhesive. We explain how preservation of natural tissue amines provides biocompatibility for PEG/dextran that exceeds the stringent, destructive cyanide‐based chemistry of cyanoacrylates, and adhere far better than fibrin glue. Strategic variations of material composition allow for the improvement of biocompatibility and adhesion strength. Material variations can be tailored to match the needs of specific tissue beds for an array of clinical applications. PEG/dextran cohesive properties are most responsive to variations in the PEG component (number of arms and solid content), while tissue/material adhesion strength is primarily determined by the number of aldehydes in the dextran.